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Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day.

Novartis Diovan Manufacturing Plant, Schweizerhalle, Switzerland

Drink adequate fluids to prevent from becoming dehydrated. If you are on restricted fluid intake, consult your doctor for further instructions. Do not take potassium supplements or salt substitutes containing potassium without talking to your doctor or pharmacist first. Tell your doctor immediately if these effects occur. The dosage is based on your medical condition and response to therapy.

For the treatment of high blood pressure, it may take 4 weeks before the full benefit of this drug occurs.

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It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. You may experience dizziness, lightheadedness, blurred vision, or tiredness as your body adjusts to the medication. You may also experience diarrhea, dry mouth, nausea, vomiting, or cough. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these unlikely but serious side effects occur: unusual thirst, weakness, confusion, fainting, fast heartbeat, decreased sexual ability.

Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: unusual change in the amount of urine after the first several days of starting this drug , signs of infection e. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling especially of the face, lips, tongue, or throat , severe dizziness, trouble breathing.

If you notice other effects not listed above, contact your doctor or pharmacist.

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This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: urinary problems inability to make urine or anuria. This drug may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. Before having surgery, tell your doctor or dentist that you are taking this medication. Hydrochlorothiazide may make you more sensitive to the sun.

Avoid prolonged sun exposure, tanning booths or sunlamps. Use a sunscreen and wear protective clothing when outdoors. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially the dizziness effect. This medication should be used only when clearly needed during the first three months of pregnancy. It is not recommended for use during the last six months of the pregnancy due to the risk for fetal harm. Discuss the risks and benefits with your doctor. See also the Warning section. Hydrochlorothiazide passes into breast milk.

Breast-feeding is not recommended due to the potential harm to the nursing infant. Consult your doctor before breast-feeding.

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This drug should not be used with the following medications because very serious interactions may occur: cisapride, dofetilide. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: ACE inhibitors e.

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This project completed a rational production concept that had already been implemented at plants at Schweizerhalle and at the Klybeck site in Basel. Because of its formula, Diovan is not only effective but also safe and well tolerated. At present, the drug is available for the treatment of hypertension in over 80 countries and in 50 for heart failure and has been used by over a million patients. Diovan has played a starring role in the Novartis portfolio and helped push growth at the company from to Novartis is the product of the mega-merger of Basel-based Ciba-Geigy and Sandoz.

Its goal is to be one of the top three companies in immunology, cardiovascular and anti-inflammatory treatments. In September Novartis completed a CHF60m expansion of the Schweizerhalle manufacturing facility to increase production capacity for Diovan valsartan. The expansion added 25 new employees. In , following EU approval of the hypertension drug Rasilez aliskiren , Novartis unveiled plans for a new major expansion to the Schweizerhalle plant. Production of Diovan will increase by 60t per year to meet global demand.

But Rasilez is a drug for the future which could eclipse Diovan. In Novartis invested CHF75m into the Schweizerhalle site to fund the construction of a chemical manufacturing unit for active pharmaceutical ingredients.

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